Our research interests center on reproductive biology and women’s health, with an emphasis on aging. Active areas of research include:

Reproductive aging, oocyte dysfunction, and mitochondrial heterogeneity:

          Mitochondrial heterogeneity in oocytes, and age-related shifts in molecular-defined mitochondrial subpopulations

Novel methods to evaluate mitochondrial subpopulations based on multiple parameters, and elucidation of the role of nuclear signaling to specific mitochondrial groups within a cell

Reproductive Biology:

Understanding the complex interactions between germline and soma (granulosa cells and their precursors) during follicle formation and growth, and how aging impacts these relationships

Stem cells as a model for ovarian somatic cell fate determination, and the utility of ‘synthetic’ stem cell-derived granulosa cells in regeneration and in application toward a bioengineered artificial ovary

Ex vivo ovarian modeling

 

Lab Updates

2017 Annual meeting for the Society for Reproductive Investigation was held in Orlando, Florida on March 15-18 where Alisha Bothun and Christine Faraci presented research posters, and Julie MacDonald presented a talk.

This August we said goodbye to our 2017 REU students soumba traore and lakshmi batachari. They did great work in collaboration with the khrakpo lab researching mitochondrial damage over time in culture cells. Congrats soumba and lakshmi!

This August we said goodbye to our 2017 REU students soumba traore and lakshmi batachari. They did great work in collaboration with the khrakpo lab researching mitochondrial damage over time in culture cells. Congrats soumba and lakshmi!

2016 REU student Eduardo Biala, Jr presented his summer research project at the Annual Biomedical Research Conference for Minority Students 2016 in Tampa Bay, Florida November 9-12th, 2016. Congrats, Ed and great job this summer!

2016 REU student Eduardo Biala, Jr presented his summer research project at the Annual Biomedical Research Conference for Minority Students 2016 in Tampa Bay, Florida November 9-12th, 2016. Congrats, Ed and great job this summer!

LAIR co-director Dr. Jonathan Tilly was the recipient of the Excellence in Research and Creative Activity Award. Jon was honored at the Academic Honors Convocation for his contributions to the field with national and international significance.

The NSF awarded Honorable Mentions to Sofia Annis and Robert Logan, graduate students of the Khrapko Lab, for their Graduate Research Fellowship proposals.  Congratulations!

Chapter contribution to the Encyclopedia of Cancer on granulosa cell tumors in press- nice work, Alisha!

2016 Annual Meeting for the Society for Reproductive Investigation was held in Montreal, Canada March 16-19th. Graduate students Julie MacDonald and Alisha Truman presented a talk and a poster, respectively.

Society for Reproductive Investigation 2015 Scientist Dr. Kshama Chandrasekhar was awarded with the 2015 SRI/Pfizer President's Presenter Award! Congrats Kshama!