Our research interests center on reproductive biology and women’s health, with an emphasis on aging. Active areas of research include:

Reproductive Biology:

Understanding the complex interactions between germline and soma (granulosa cells and their precursors) during follicle formation and growth, and how aging impacts these relationships

Stem cells as a model for ovarian somatic cell fate determination, and the utility of ‘synthetic’ stem cell-derived granulosa cells in regeneration and in application toward a bioengineered artificial ovary

Ex vivo ovarian modeling

Reproductive aging, oocyte dysfunction, and mitochondrial heterogeneity:

          Mitochondrial heterogeneity in oocytes, and age-related shifts in molecular-defined mitochondrial subpopulations

Novel methods to evaluate mitochondrial subpopulations based on multiple parameters, and elucidation of the role of nuclear signaling to specific mitochondrial groups within a cell

Lab Updates

The LAIR's very own Dr. Jonathan Tilly was the recipient of the Excellence in Research and Creative Activity Award. Jon was honored at the Academic Honors Convocation for his contributions to the field with national and international significance.

The NSF awarded Honorable Mentions to Sofia Annis and Robert Logan, graduate students of the Khrapko Lab, for their Graduate Research Fellowship proposals.  Congratulations!

Chapter contribution to the Encyclopedia of Cancer on granulosa cell tumors in press- nice work, Alisha!

Annual Meeting for the Society for Reproductive Investigation 2016 will be held in Montreal, Canada March 16-19th. Graduate students Julie MacDonald and Alisha Truman will present a talk and a poster, respectively.

Society for Reproductive Investigation 2015 Scientist Dr. Kshama Chandrasekhar was awarded with the 2015 SRI/Pfizer President's Presenter Award! Congrats Kshama!