Our research interests center on reproductive biology and women’s health, with an emphasis on aging. Active areas of research include:

Reproductive aging, oocyte dysfunction, and mitochondrial heterogeneity:

          Mitochondrial heterogeneity in oocytes, and age-related shifts in molecular-defined mitochondrial subpopulations

Novel methods to evaluate mitochondrial subpopulations based on multiple parameters, and elucidation of the role of nuclear signaling to specific mitochondrial groups within a cell

Reproductive Biology:

Understanding the complex interactions between germline and soma (granulosa cells and their precursors) during follicle formation and growth, and how aging impacts these relationships

Stem cells as a model for ovarian somatic cell fate determination, and the utility of ‘synthetic’ stem cell-derived granulosa cells in regeneration and in application toward a bioengineered artificial ovary

Ex vivo ovarian modeling

 

Lab Updates

July 2019 Sofia and Zoe published in PNAS! Congratulations! This response paper is on paternal inheritance of mitochondrial DNA. Link below:

https://www.pnas.org/content/early/2019/07/15/1821436116

https://figshare.com/s/2c0d2508a0245b5e118f

July 2019 Fluorescence-activated mitochondria sorting (FAMS), a technique developed and validated in the LAIR, has been published in Communications Biology. Congratulations to all who contributed; especially to the co-first authors, Julie and Alisha! Link to publication below:

https://www.nature.com/articles/s42003-019-0513-4

May 2019 Congratulations to our graduates Dr. Alisha Bothun and Dr. Julie MacDonald on the completion of their PhD’s!

DR. MACDONALD AND DR. BOTHUN AT THEIR HOODING and Graduation CEREMONY.

DR. MACDONALD AND DR. BOTHUN AT THEIR HOODING and Graduation CEREMONY.

May 2019 Congratulations to Taichi Akahori on his publication in Clinical Medicine Insights: Reproductive Health.

April 2019 Congratulations to Julie MacDonald on her publication in Fertility and sterility.

March 2019 Julie MacDonald and Jessica Martin presented their research at the Society for Reproductive Investigation (SRI) Annual Meeting in Paris, France.

February 2019 Congratulations to Alisha Bothun on her publication in Histochemistry and cell biology.

February 2019 Congratulations to Jessica Martin on her publication in Cells.

February 2019 Hannah Sheehan was invited and gave a talk at the University Hospital Regensburg in Regensburg, Germany.

Spring/Summer 2019 Congratulations for BS/Ph.D. student Fausto Capelluto on receiving the following awards:

Lucille Zanghi ’72 and Jim Dow ‘72 21st Century Scholarship 2019

HSF (Hispanic Scholarship Fund) Scholar 2019

Advanced Research/Creative Endeavor Award (UGRCE)

Summer Scholars Independent Research Fellowship (SSIRF)

October 2018 Congrats to graduate student Julie MacDonald and two LAIR undergraduate students, Nikki and Carleigh, on their publication in the Journal of Ovarian Research!

2018 Congratulations to lab alumna Christine Faraci and collaborator Sofia Annis on their recently accepted paper in Reproduction, Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.

May 2018 Alisha Bothun's paper was accepted to Stem Cells and Development, and her image was chosen for the cover!

StemCellsDev Cover Image.jpg

2018 The Northeastern chapter of the College Diabetes Network (CDN), advised by Dr. Woods, has officially launched! See the recent article about it here or their Facebook page for more info.

2018 Woods lab awarded prestigious NSF CAREER award for work on mitochondrial heterogeneity and function. Congratulations to all graduate student and undergraduate student contributors on their excellent scientific efforts!

In December 2017, the Woods lab celebrated Christine Faraci as she graduated with her Master's degree! Congratulations Christine!

2017 Annual meeting for the Society for Reproductive Investigation was held in Orlando, Florida on March 15-18 where Alisha Bothun and Christine Faraci presented research posters, and Julie MacDonald presented a talk.

This August we said goodbye to our 2017 REU students soumba traore and lakshmi batachari. They did great work in collaboration with the khrakpo lab researching mitochondrial damage over time in culture cells. Congrats soumba and lakshmi!

This August we said goodbye to our 2017 REU students soumba traore and lakshmi batachari. They did great work in collaboration with the khrakpo lab researching mitochondrial damage over time in culture cells. Congrats soumba and lakshmi!

2016 REU student Eduardo Biala, Jr presented his summer research project at the Annual Biomedical Research Conference for Minority Students 2016 in Tampa Bay, Florida November 9-12th, 2016. Congrats, Ed and great job this summer!

2016 REU student Eduardo Biala, Jr presented his summer research project at the Annual Biomedical Research Conference for Minority Students 2016 in Tampa Bay, Florida November 9-12th, 2016. Congrats, Ed and great job this summer!

 

LAIR co-director Dr. Jonathan Tilly was the recipient of the Excellence in Research and Creative Activity Award. Jon was honored at the Academic Honors Convocation for his contributions to the field with national and international significance.

The NSF awarded Honorable Mentions to Sofia Annis and Robert Logan, graduate students of the Khrapko Lab, for their Graduate Research Fellowship proposals.  Congratulations!

Chapter contribution to the Encyclopedia of Cancer on granulosa cell tumors in press- nice work, Alisha!

2016 Annual Meeting for the Society for Reproductive Investigation was held in Montreal, Canada March 16-19th. Graduate students Julie MacDonald and Alisha Truman presented a talk and a poster, respectively.

Society for Reproductive Investigation 2015 Scientist Dr. Kshama Chandrasekhar was awarded with the 2015 SRI/Pfizer President's Presenter Award! Congrats Kshama!